The screenplay incorporates a great deal of technical information, somehow making it comprehensible, so that we can understand the reasoning when scientists like the distinguished Professor Nikolais debate the Odones. Clearly, there is something here of benefit. Michaela's faith, it turns out, was justified. Childhood onset tends to progress rapidly and typically death occurs by age 10, although lifespan can be increased if an early bone marrow transplant is given. Lorenzo's Oil provides a high dietary intake of long chain monounsaturated fatty acids thought to monopolize the specific enzyme involved in the conversion of long chain f. Smarter students may ask why only the more potent erucic acid was not used it is probably due to toxicity. The one copy of the gene is on the X chromosome and the Y chromosome lacks the second allele.
The biochemical basis of this disease is related to the metabolism of what molecules? That is, some genes that are located on the homologous sex chromosomes have only one allele not the expected two alleles for genes found in autosomal chromosomes. Were there any special attributes that the Odone family possessed which permitted them to find a way to stop the deterioration of their son's health? Do you think that the Odones were arrogant as the head of the Foundation claimed? When Lorenzo is diagnosed with Adrenoleukodystrophy, the doctor explains the prognosis for this disorder. How could the results of Hugo Moser's study Sept, 2002 conclude that Loenzo's Oil works yet those of Aubourg et al. The disease was only first described ten years before, and no one had warned her that she needed genetic counseling. His was given 2 years to die. Will society allow embryos to be created to obtain stem cells to treat Lorenzo and other children with demyelinating diseases? Refusing to give up hope, Ms.
Will both girls and boys be affected with equal probability? Lorenzo has been on this treatment and it has worked. Doctors said that he would lose all his functions and die within two to three years. In addition, it is an attempt to use the story of the Odone's to inspire students to learn more about cell biology. The award is not limited to U. Thus, both the breakdown and the synthesis of very long chain fatty acids is by removal or addition of two carbon units.
It is unfair and misleading, for those new ideas that turn out to be true, to look back at previous skepticism as nihilistic or obstructionist. Without myelin, nerves can't function normally, or at all. Financially, they were well off, and when Lorenzo first became ill, they had no mortgages on their home. However, the very long chain fatty acids are unusual in that they are broken down by ß-oxidation in the peroxisome short chain fatty acid breakdown occurs mostly in the mitochondrium. We decided to take matters into our own hands and researched everything from the disease itself, to the basis of how fatty acids are broken down in the body. This is an excellent model identifying a disease, getting or providing funding, and then using those resources to do science targeted at understanding and curing the disease.
Give an example of an anecdotal result from the movie. Daughters also will inherit the bad gene 50% of the time, but they will not have the inherited disease because they will have a second, normal gene on the other X chromosome. This provides an opportunity to review basic genetics. He begins to have strange memory problems and blackouts. The Odones only had Lorenzo's interests at heart.
What was the role of luck in the Odones' search for a way to stop the deterioration of Lorenzo's condition? This test does not include questions about: 1 genetics see ; 2 the scientific method, see ; and 3 the medical ethics of clinical trials for a short quiz on that topic. She did not think it was fair for her to enjoy life when he could not. Suggested Response: Determination, intelligence, education and sufficient assets to devote money to the effort of finding a cure. A 1960 recording of with the orchestra and chorus is heard singing selections from Bellini's at several points. For example, it reduces platelet count. Suggested Response: Here are three: 1 The Christ story of someone who suffers for the benefit of others; 2 The struggle of people against a heartless nature; 3 the struggle of powerless people against a large institution in society.
In adult onset, symptoms may not appear until adulthood, and then tends to progress more slowly, over decades. Some symptoms shown in the movie Lorenzo's Oil were hyperactive, clumsy, audio difficulty, and seizures. This is the scientific version of Monday morning quarterbacking. In Lorenzo his c24 and c26 rises four times its normal average. Suggested Response: The agent of the harsh and uncaring nature was their own genes. The Odones train themselves in biology to develop a treatment for their son.
Should you be prevented from having a child by law? Explain them and how models and explanations were developed for both. Why are boys more likely to have an inherited recessive disease than a girl? She suggests a reason why the use of erucic acid did not turn out to be harmful as the physicians initially believed. Suggested Response: Symptoms include 1 poor memory; 2 loss of emotional control; 3 dementia; 4 muscle weakness; 5 difficulty in walking; 6 spasticity; 7 deficiencies with hearing; 8 problems with speech; 9 problems with vision; 10 deteriorated muscle tone; 11 difficulty swallowing; and 12 coma. This is also why, no matter how good the story sounds, we still have to do the detailed science, ask all the hard questions, and show that a new treatment actually works. All of our doctors will not act on this issue. The Odones developed an special combination of fats a mixture of 4:1 glyceryl trioleate —glyceryl trierucate that helped his son to fight the disease. Lipid Structure Over the past 15 years, the impact of lipid biology on our daily lives has increased and lipid research has become a hot area.
Despite research dead-ends, the horror of watching their son's health decline, and being surrounded by skeptics including the coordinators of the support group they attend , they persist until they finally hit upon a therapy involving adding a certain kind of actually containing two specific , isolated from and to their son's diet. The sympathetic portrayal rarely fails to become an indelible memory for my students. We found that the reason that the diet is not working is because the absence of all saturated fats provokes the body to make even more of the long chain fatty acids. Unsaturated fats obtained from plants e. Lorenzo was born in 1978. What is ironic about this theme in its application to the experience of Lorenzo and Michaela Odone? Advertisement Some assume that the doctors know best - as, indeed, usually they do. If the inherited disease was not sex-linked and both parents were carriers, would you have a child calculate the odds of having a child with the inherited disease; see student questions below? Hydrogenation removes the kinks in the fatty acid chain and allows the triglycerides to pack together well.
Such stories are like catnip to journalists and Hollywood; they cannot resist them, or resist shoehorning them into their preferred narratives. Based on a true story with Susan Sarandon and Nick Nolte playing the parents Michalla and Augosto Odone of Lorenzo who is played by Peter Ustinov. The first is that a cure can be found for any illness if only the bureaucracy and red tape will get out of the way. Would it make a difference if you knew it was a girl or a boy? These fatty acids have a very long hydrophobic tail the uncharged carbon chain and a charged carboxyl group at one end. . Suggested Response: A saturated fatty acid with a very long hydrocarbon tail.